Glyburide Side Effects

Glyburide Induced Hypoglycemia

The most common and difficult of the glyburide side effects is hypoglycemia. Hypoglycemia, otherwise known as low blood sugar, is a common side effect of all the medications in the sulfonylurea class of drugs. Glyburide is usually used as a once or twice daily oral medication for type II diabetes and because of its relatively long half-life of approximately 10 hours frequently the effective glyburide continues long after a person has last eaten. At times when an individual using glyburide goes long periods of time without eating glyburide can continue to stimulate pancreatic insulin secretion and drive blood sugars abnormally low. This is especially a problem when a person becomes ill and is unable ingest and absorb adequate nutrition.

There’s an increasing body of evidence that recurrent episodes of significant hypoglycemia can lead to permanent neurologic dysfunction. It’s felt that hypoglycemia may occur in patients using the derived during sleep also and be relatively asymptomatic yet potentially harmful. For this reason medications less likely to be at associated with hypoglycemia have become more popular in the modern treatment of type II diabetes. These types of medication include first metformin. Metformin has the advantage of reducing the production and release of glucose from hepatic and muscle cells and thereby lowering average serum blood sugars without leading to hypoglycemia during prolonged fasts. Additionally medications that specifically target the incretin system have become more popular. These medications include to types of medications. The oral DPP4 antagonists block the usually rapid metabolism of encrypted released after eating which stimulate the pancreas to release insulin. Examples of DPP4 inhibitors are Januvia and on Onglyza. The injectable medications that directly stimulate the pancreas to release insulin after meals function as incretin like substances, and include Byetta, Victoza, and Budureon. Another advantage of this latter class of medications is that especially at higher doses they are sometimes associated with weight loss where as many of the other oral medications including the derived a more often associated with weight gain. This is especially helpful in patients with type II diabetes as weight gain can lead to increased insulin resistance and higher blood sugars whereas with weight loss the inverse may be true.

Alternative sulfonylureas are sometimes used instead of glyburide. Glymepiride, trade name Amaryl, is sometimes recommended although with a serum half-life of approximately 9.2 hours any advantage in less and hypoglycemia is probably minimal. Most experts recommend that if glyburide or other sulfonylureas are used in the treatment of type II diabetes now the dose be kept


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